diff --git a/config/app_config.yaml b/config/app_config.yaml
new file mode 100644
index 0000000..56a171e
--- /dev/null
+++ b/config/app_config.yaml
@@ -0,0 +1,48 @@
+database:
+  path: "data/detections.db"
+
+image_repository:
+  base_path: ""  # Set by user through GUI
+  allowed_extensions:
+    - ".jpg"
+    - ".jpeg"
+    - ".png"
+    - ".tif"
+    - ".tiff"
+    - ".bmp"
+
+models:
+  default_base_model: "yolov8s.pt"
+  models_directory: "data/models"
+
+training:
+  default_epochs: 100
+  default_batch_size: 16
+  default_imgsz: 640
+  default_patience: 50
+  default_lr0: 0.01
+
+detection:
+  default_confidence: 0.25
+  default_iou: 0.45
+  max_batch_size: 100
+
+visualization:
+  bbox_colors:
+    organelle: "#FF6B6B"
+    membrane_branch: "#4ECDC4"
+    default: "#00FF00"
+  bbox_thickness: 2
+  font_size: 12
+
+export:
+  formats:
+    - csv
+    - json
+    - excel
+  default_format: "csv"
+
+logging:
+  level: "INFO"
+  file: "logs/app.log"
+  format: "%(asctime)s - %(name)s - %(levelname)s - %(message)s"
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