minor adjustments after trial and error
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16
Model.py
16
Model.py
@ -197,13 +197,9 @@ class Model:
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# Bi = (1 + (self.CMDN_tot * self.Km_CMDN)/(self.Km_CMDN+(Cai))**2)**(-1)
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# Bss = 1 / ((self.CMDN_tot * self.Km_CMDN) / (self.Km_CMDN + Cass) ** 2)
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Bi = 1 / (
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1 + (self.CMDN_tot * self.Km_CMDN) / (self.Km_CMDN + Cai) ** 2
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)
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Bi = 1 / (1 + (self.CMDN_tot * self.Km_CMDN) / (self.Km_CMDN + Cai) ** 2)
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Bss = 1 / (
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1 + (self.CMDN_tot * self.Km_CMDN) / (self.Km_CMDN + Cass) ** 2
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)
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Bss = 1 / (1 + (self.CMDN_tot * self.Km_CMDN) / (self.Km_CMDN + Cass) ** 2)
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J_xfer = (Cass - Cai) / self.tau_xfer
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@ -216,9 +212,7 @@ class Model:
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J_trpn = (
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self.k_htrpn_positive * Cai * (self.HTRPN_tot - HTRPNCa)
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- self.k_htrpn_negative * HTRPNCa
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+ self.k_ltrpn_positive
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* Cai
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* (self.LTRPN_tot - LTRPNCa)
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+ self.k_ltrpn_positive * Cai * (self.LTRPN_tot - LTRPNCa)
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- self.k_ltrpn_negative * LTRPNCa
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)
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@ -258,9 +252,7 @@ class Model:
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P_C1 = 1 - (P_C2 + P_O1 + P_O2)
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dP_O1dt = (
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self.k_a_positive * (Cass) ** self.n_ryr * P_C1
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)
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dP_O1dt = self.k_a_positive * (Cass) ** self.n_ryr * P_C1
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-self.k_a_negative * P_O1 - self.k_a_positive * (Cass) ** self.m_ryr * P_O1
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+self.k_b_negative * P_O2 - self.k_c_positive * P_O1 + self.k_c_negative * P_C2
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@ -61,7 +61,12 @@ class Fitter:
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model.K_pc_half = K_pc_half
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model.tau_xfer = tau_xfer
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model.solve(times=self.time_points, tspan=self.tspan, dt=self.dt, initial_values=self.initial_values)
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model.solve(
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times=self.time_points,
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tspan=self.tspan,
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dt=self.dt,
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initial_values=self.initial_values,
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)
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_calc_curr = model.calculated_current()
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calculated_current = (
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@ -207,7 +212,7 @@ if __name__ == "__main__":
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eid_cleaned = re.sub(
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r"[^\w.-]", "", eid
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) # Eemalda kõik eritähed ja jääb alles alphanumbrilised tähed, sidekriipsud ja punktid
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) # Eemaldab eritahed
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fig.savefig(f"plot_{eid_cleaned}.png")
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fig.savefig(f"plot_{eid_cleaned}.pdf")
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